2024

Colocalization of cancer-associated biomarkers on single extracellular vesicles for early detection of cancer.
Salem DP, Bortolin LT, Gusenleitner D, Grosha J, Zabroski IO, Biette KM, Sanchari S, Sedlak CR, Byrne DM, Hamzeh BF, King MS, Cuoco LT, Santos-Heiman T, Barcaskey GN, Yang KS, Duff PA, Winn-Deen ES, Guettouche T, Mattoon DR, Huang EK, Schekman R, Couvillon AD, Sedlak JC.
J Mol Diagnostics [In Press]. doi: 10.1016/j.jmoldx.2024.08.006

Intercellular transmission of alpha-synuclein.
Wu S, Schekman R.
Front Mol Neurosci. 2024 Sep 11;17:1470171. doi: 10.3389/fnmol.2024.1470171. PMID: 39324117.

Calpains orchestrate secretion of annexin-containing microvesicles during membrane repair.
Williams JK, Ngo JM, Murugupandiyan A, Croall DE, Hartzell HC, Schekman R.
bioRxiv [Preprint]. 2024 Sep 7.2024.09.05.611512. doi: 10.1101/2024.09.05.611512.

Mechanism-guided engineering of a minimal biological particle for genome editing.
Ngo W, Peukes JT, Baldwin A, Xue ZW, Hwang S, Stickels RR, Lin Z, Satpathy AT, Wells JA, Schekman R, Nogales E, Doudna JA.
bioRxiv [Preprint]. 2024 Jul 24:2024.07.23.604809. doi: 10.1101/2024.07.23.604809. PMID: 39091760.

Characterization of the interaction between the Sec61 translocon complex and ppαF using optical tweezers.
Robeson L, Casanova-Morales N, Burgos-Bravo F, Alfaro-Valdés HM, Lesch R, Ramírez-Álvarez C, Valdivia-Delgado M, Vega M, Matute RA, Schekman R, Wilson CAM.
Protein Sci. 2024 Jun;33(6):e4996. doi: 10.1002/pro.4996. PMID: 38747383.

Proteins that carry dual targeting signals can act as tethers between peroxisomes and partner organelles.
Bittner E, Stehlik T, Lam J, Dimitrov L, Heimerl T, Schöck I, Harberding J, Dornes A, Heymons N, Bange G, Schuldiner M, Zalckvar E, Bölker M, Schekman R, Freitag J.
PLoS Biol. 2024 Feb 20;22(2):e3002508. doi: 10.1371/journal.pbio.3002508. PMID: 38377076.

2023

From policy to practice: Lessons learned from an open science funding initiative.
Dumanis SB, Ratan K, McIntosh S, Shah HV, Lewis M, Vines TH, Schekman R, Riley EA.
PLoS Comput Biol. 2023 Dec 7;19(12):e1011626. doi: 10.1371/journal.pcbi.1011626. PMID: 38060981.

Biochemical reconstitution of Ca2+-dependent exosome secretion in permeabilized mammalian cells.
Ngo JM, Williams JK, Lehman IM, Schekman R.
Bio Protoc. 2023 Dec 5;13(23):e4890. doi: 10.21769/BioProtoc.4890. PMID: 38094256.

Two RNA-binding proteins mediate the sorting of miR223 from mitochondria into exosomes.
Ma L, Singh J, Schekman R.
Elife. 2023 Jul 25;12:e85878. doi: 10.7554/eLife.85878. PMID: 37489754.

Annexin A6 mediates calcium-dependent exosome secretion during plasma membrane repair.
Williams JK*, Ngo JM*, Lehman IM, Schekman R. (*equal contribution)
Elife. 2023 May 19;12:e86556. doi: 10.7554/eLife.86556. PMID: 37204294.

Chemical disaggregation of alpha-synuclein fibrils as a therapy for synucleinopathies.
Wu S, Hernandez Villegas NC, Schekman R.
Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2300965120. doi: 10.1073/pnas.2300965120. PMID: 36888654.

Syncytin-mediated open-ended membrane tubular connections facilitate the intercellular transfer of cargos including Cas9 protein.
Zhang C, Schekman R.
Elife. 2023 Mar 10;12:e84391. doi: 10.7554/eLife.84391. PMID: 36896791.

Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers.
Wu S, Hernandez Villegas NC, Sirkis DW, Thomas-Wright I, Wade-Martins R, Schekman R.
Elife. 2023 Jan 10;12:e85837. doi: 10.7554/eLife.85837. PMID: 36626307.

2021

Selective sorting of microRNAs into exosomes by phase-separated YBX1 condensates.
Liu XM, Ma L, Schekman R.
Elife. 2021 Nov 12;10:e71982. doi: 10.7554/eLife.71982. PMID: 34766549.

APEX-mediated Proximity Labeling of Proteins in Cells Targeted by Extracellular Vesicles.
Song L, Chen J, Sun A, Schekman R.
Bio Protoc. 2021 Nov 5;11(21):e4213. doi: 10.21769/BioProtoc.4213. PMID: 34859128

Low-bias ncRNA libraries using ordered two-template relay: Serial template jumping by a modified retroelement reverse transcriptase.
Upton HE, Ferguson L, Temoche-Diaz MM, Liu XM, Pimentel SC, Ingolia NT, Schekman R, Collins K.
Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2107900118. doi: 10.1073/pnas.2107900118. PMID: 34649994.

Extracellular vesicles from neurons promote neural induction of stem cells through cyclin D1.
Song L, Tian X, Schekman R.
J Cell Biol. 2021 Sep 6;220(9):e202101075. doi: 10.1083/jcb.202101075. PMID: 34309628.

Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum.
Wouters R, Michiels C, Sannerud R, Kleizen B, Dillen K, Vermeire W, Ayala AE, Demedts D, Schekman R, Annaert W.
J Cell Biol. 2021 Sep 6;220(9):e201911104. doi: 10.1083/jcb.201911104. Epub 2021 Jul 22. PMID: 34292306.

Open science takes on Parkinson's disease.
Riley EA, Schekman R.
Elife. 2021 Feb 25;10:e66546. doi: 10.7554/eLife.66546. PMID: 33629954.

2020

Buoyant Density Fractionation of Small Extracellular Vesicle Sub-populations Derived from Mammalian Cells.
Temoche-Diaz MM, Shurtleff MJ, Schekman R.
Bio Protoc. 2020 Aug 5;10(15):e3706. doi: 10.21769/BioProtoc.3706. eCollection 2020 Aug 5.PMID: 33659370

A CLN6-CLN8 complex recruits lysosomal enzymes at the ER for Golgi transfer.
Bajaj L, Sharma J, di Ronza A, Zhang P, Eblimit A, Pal R, Roman D, Collette JR, Booth C, Chang KT, Sifers RN, Jung SY, Weimer JM, Chen R, Schekman RW, Sardiello M.
J Clin Invest. 2020 Aug 3;130(8):4118-4132. doi: 10.1172/JCI130955. PMID: 32597833.

Small sequence variations between two mammalian paralogs of the small GTPase SAR1 underlie functional differences in coat protein complex II assembly.
Melville DB, Studer S, Schekman R.
J Biol Chem. 2020 Jun 19;295(25):8401-8412. doi: 10.1074/jbc.RA120.012964. PMID: 32358066.

In Memoriam: Lelio Orci, 1937–2019.
Montesano R, Schekman R, Rothman J, Perrelet A.
Proc Natl Acad Sci U S A. 2020 Jan 7; 117(1): 15–17. doi: 10.1073/pnas.1920094117 PMCID: PMC6955317

2019

New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells.
Bassaganyas L, Popa SJ, Horlbeck M, Puri C, Stewart SE, Campelo F, Ashok A, Butnaru CM, Brouwers N, Heydari K, Ripoche J, Weissman J, Rubinsztein DC, Schekman R, Malhotra V, Moreau K, Villeneuve J.
J Cell Biol. 2019 Nov 4;218(11):3861-3879. doi: 10.1083/jcb.201902028. PMID: 31488582.

Coordinating a new approach to basic research into Parkinson's disease.
Schekman R, Riley EA.
Elife. 2019 Sep 25;8:e51167. doi: 10.7554/eLife.51167. PMID: 31551111.

Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes.
Temoche-Diaz MM, Shurtleff MJ, Nottingham RM, Yao J, Fadadu RP, Lambowitz AM, Schekman R.
Elife. 2019 Aug 22;8:e47544. doi: 10.7554/eLife.47544. PMID: 31436530.

Regulation of LC3 lipidation by the autophagy-specific class III phosphatidylinositol-3 kinase complex.
Brier LW, Ge L, Stjepanovic G, Thelen AM, Hurley JH, Schekman R.
Mol Biol Cell. 2019 Apr 15;30(9):1098-1107. doi: 10.1091/mbc.E18-11-0743. PMID: 30811270.

Fatty-acid binding protein 5 modulates the SAR1 GTPase cycle and enhances budding of large COPII cargoes.
Melville D, Gorur A, Schekman R.
Mol Biol Cell. 2019 Feb 1;30(3):387-399. doi: 10.1091/mbc.E18-09-0548. PMID: 30485159.

Progress and promise.
Schekman R.
Elife. 2019 Jan 23;8:e44799. doi: 10.7554/eLife.44799. PMID: 30672736.

2018

TANGO1 and SEC12 are copackaged with procollagen I to facilitate the generation of large COPII carriers.
Yuan L, Kenny SJ, Hemmati J, Xu K, Schekman R.
Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12255-E12264. doi: 10.1073/pnas.1814810115. PMID: 30545919.

A new twist on peer review.
Patterson M, Schekman R.
Elife. 2018 Jun 26;7:e36545. doi: 10.7554/eLife.36545. PMID: 29944117.

A mechanism for differential sorting of the planar cell polarity proteins Frizzled6 and Vangl2 at the trans-Golgi network.
Ma T, Li B, Wang R, Lau PK, Huang Y, Jiang L, Schekman R, Guo Y.
J Biol Chem. 2018 Jun 1;293(22):8410-8427. doi: 10.1074/jbc.RA118.001906. Epub 2018 Apr 17. PMID: 29666182.

How early-career researchers are shaping eLife.
Patterson M, Schekman R.
Elife. 2018 Mar 27;7:e36263. doi: 10.7554/eLife.36263. PMID: 29583120.

Transparency in authors' contributions and responsibilities to promote integrity in scientific publication.
McNutt MK, Bradford M, Drazen JM, Hanson B, Howard B, Jamieson KH, Kiermer V, Marcus E, Pope BK, Schekman R, Swaminathan S, Stang PJ, Verma IM.
Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2557-2560. doi: 10.1073/pnas.1715374115. PMID: 29487213.

Extracellular Vesicles and Cancer: Caveat Lector.
Shurtleff MJ, Temoche-Diaz MM, Schekman R.
Annu Rev Cancer Bio. 2018 2:1, 395-411. doi: 10.1146/annurev-cancerbio-030617-050519.

Unconventional secretion of FABP4 by endosomes and secretory lysosomes.
Villeneuve J, Bassaganyas L, Lepreux S, Chiritoiu M, Costet P, Ripoche J, Malhotra V, Schekman R.
J Cell Biol. 2018 Feb 5;217(2):649-665. doi: 10.1083/jcb.201705047. PMID: 29212659.

2017

Cell-free Generation of COPII-coated Procollagen I Carriers.
Yuan L, Baba S, Bajaj K, Schekman R.
Bio Protoc. 2017 Nov 20;7(22):e2450. doi: 10.21769/BioProtoc.2450. PMID: 29276723.

Broad role for YBX1 in defining the small noncoding RNA composition of exosomes.
Shurtleff MJ*, Yao J*, Qin Y, Nottingham RM, Temoche-Diaz MM, Schekman R#, Lambowitz AM#. (*equal contribution, #co-corresponding authors)
Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E8987-E8995. doi: 10.1073/pnas.1712108114. PMID: 29073095.

Room at the top.
Schekman R.
Elife. 2017 Oct 12;6:e31697. doi: 10.7554/eLife.31697. PMID: 29021081.

Introduction: The Challenge to Science in the Arena of Public Policy.
Schekman R.
Annu Rev Cell Dev Biol. 2017 Oct 6;33:v-vii. doi: 10.1146/annurev-cb-33-092017-100001. PMID: 28992435.

Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER-Golgi intermediate compartment.
Sirkis DW, Aparicio RE, Schekman R.
Mol Biol Cell. 2017 Oct 1;28(20):2723-2733. doi: 10.1091/mbc.E17-06-0423. PMID: 28768830.

Remodeling of ER-exit sites initiates a membrane supply pathway for autophagosome biogenesis.
Ge L#, Zhang M, Kenny SJ, Liu D, Maeda M, Saito K, Mathur A, Xu K, Schekman R#. (#co-corresponding authors)
EMBO Rep. 2017 Sep;18(9):1586-1603. doi: 10.15252/embr.201744559. PMID: 28754694.

TFG facilitates outer coat disassembly on COPII transport carriers to promote tethering and fusion with ER-Golgi intermediate compartments.
Hanna MG 4th, Block S, Frankel EB, Hou F, Johnson A, Yuan L, Knight G, Moresco JJ, Yates JR 3rd, Ashton R, Schekman R, Tong Y, Audhya A.
Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7707-E7716. doi: 10.1073/pnas.1709120114. PMID: 28851831.

COPII-coated membranes function as transport carriers of intracellular procollagen I.
Gorur A*, Yuan L*, Kenny SJ, Baba S, Xu K, Schekman R. (*equal contribution)
J Cell Biol. 2017 Jun 5;216(6):1745-1759. doi: 10.1083/jcb.201702135. PMID: 28428367.

2016

Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor.
McGourty CA, Akopian D, Walsh C, Gorur A, Werner A, Schekman R, Bautista D, Rape M.
Cell. 2016 Oct 6;167(2):525-538.e14. doi: 10.1016/j.cell.2016.09.026.PMID: 27716508 

Building a sustainable future for eLife.
Schekman R, Patterson M.
Elife. 2016 Sep 29;5:e21230. doi: 10.7554/eLife.21230.PMID: 27681279 

Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction.
Shurtleff MJ, Temoche-Diaz MM, Karfilis KV, Ri S, Schekman R.
Elife. 2016 Aug 25;5:e19276. doi: 10.7554/eLife.19276.PMID: 27559612 

Distinct stages in the recognition, sorting, and packaging of proTGFα into COPII-coated transport vesicles.
Zhang P, Schekman R.
Mol Biol Cell. 2016 Jun 15;27(12):1938-47. doi: 10.1091/mbc.E16-02-0090. Epub 2016 Apr 27.PMID: 27122606 

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, …See abstract for full author list ➔
Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356.PMID: 26799652 

2015

Unique COPII component AtSar1a/AtSec23a pair is required for the distinct function of protein ER export in Arabidopsis thaliana.
Zeng Y, Chung KP, Li B, Lai CM, Lam SK, Wang X, Cui Y, Gao C, Luo M, Wong KB, Schekman R, Jiang L.
Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14360-5. doi: 10.1073/pnas.1519333112. Epub 2015 Nov 2.PMID: 26578783 

Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion.
Zhang M, Kenny SJ, Ge L, Xu K, Schekman R.
Elife. 2015 Nov 2;4:e11205. doi: 10.7554/eLife.11205.PMID: 26523392 

SCIENTIFIC INTEGRITY. Self-correction in science at work.
Alberts B, Cicerone RJ, Fienberg SE, Kamb A, McNutt M, Nerem RM, Schekman R, Shiffrin R, Stodden V, Suresh S, Zuber MT, Pope BK, Jamieson KH.
Science. 2015 Jun 26;348(6242):1420-2. doi: 10.1126/science.aab3847.PMID: 26113701 

Phosphoregulatory protein 14-3-3 facilitates SAC1 transport from the endoplasmic reticulum.
Bajaj Pahuja K, Wang J, Blagoveshchenskaya A, Lim L, Madhusudhan MS, Mayinger P, Schekman R.
Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):E3199-206. doi: 10.1073/pnas.1509119112. Epub 2015 Jun 8.PMID: 26056309 

Avoidance of autophagy mediated by PlcA or ActA is required for Listeria monocytogenes growth in macrophages.
Mitchell G, Ge L, Huang Q, Chen C, Kianian S, Roberts MF, Schekman R, Portnoy DA.
Infect Immun. 2015 May;83(5):2175-84. doi: 10.1128/IAI.00110-15. Epub 2015 Mar 16.PMID: 25776746 

Recognizing the importance of new tools and resources for research.
Schekman R, Weigel D, Watt FM.
Elife. 2015 Mar 31;4:e07083. doi: 10.7554/eLife.07083.PMID: 25824292 

Biogenesis of autophagosomal precursors for LC3 lipidation from the ER-Golgi intermediate compartment.
Ge L, Wilz L, Schekman R.
Autophagy. 2015;11(12):2372-4. doi: 10.1080/15548627.2015.1105422.PMID: 26565421 

[The genes and proteins which control the process of secretion].
Schekman R.
Biol Aujourdhui. 2015;209(1):35-61. doi: 10.1051/jbio/2015011. Epub 2015 Jun 26.PMID: 26115712 

2014

Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment.
Ge L, Zhang M, Schekman R.
Elife. 2014 Nov 28;3:e04135. doi: 10.7554/eLife.04135.PMID: 25432021 

Advancing research.
Patterson M, Schekman R, Watt FM, Weigel D.
Elife. 2014 Aug 13;3:e03980. doi: 10.7554/eLife.03980.PMID: 25122625 

The protein-vesicle network of autophagy.
Ge L, Baskaran S, Schekman R, Hurley JH.
Curr Opin Cell Biol. 2014 Aug;29:18-24. doi: 10.1016/j.ceb.2014.02.005. Epub 2014 Mar 25.PMID: 24681112 Review.

Peroxisomes are juxtaposed to strategic sites on mitochondria.
Cohen Y, Klug YA, Dimitrov L, Erez Z, Chuartzman SG, Elinger D, Yofe I, Soliman K, Gärtner J, Thoms S, Schekman R, Elbaz-Alon Y, Zalckvar E, Schuldiner M.
Mol Biosyst. 2014 Jul;10(7):1742-8. doi: 10.1039/c4mb00001c. Epub 2014 Apr 10.PMID: 24722918

Endoplasmic reticulum stress-activated transcription factor ATF6α requires the disulfide isomerase PDIA5 to modulate chemoresistance.
Higa A, Taouji S, Lhomond S, Jensen D, Fernandez-Zapico ME, Simpson JC, Pasquet JM, Schekman R, Chevet E.
Mol Cell Biol. 2014 May;34(10):1839-49. doi: 10.1128/MCB.01484-13. Epub 2014 Mar 17.PMID: 24636989 

Regulated oligomerization induces uptake of a membrane protein into COPII vesicles independent of its cytosolic tail.
Springer S, Malkus P, Borchert B, Wellbrock U, Duden R, Schekman R.
Traffic. 2014 May;15(5):531-45. doi: 10.1111/tra.12157. Epub 2014 Feb 25.PMID: 24479619 

Protein sorting at the trans-Golgi network.
Guo Y, Sirkis DW, Schekman R.
Annu Rev Cell Dev Biol. 2014;30:169-206. doi: 10.1146/annurev-cellbio-100913-013012. Epub 2014 Aug 18.PMID: 25150009 Review.

An interview with Randy Schekman and Thomas Südhof.
Schekman R, Südhof T.
Trends Cell Biol. 2014 Jan;24(1):6-8. doi: 10.1016/j.tcb.2013.11.006.PMID: 24516885 

The ER-Golgi intermediate compartment feeds the phagophore membrane.
Ge L, Schekman R.
Autophagy. 2014 Jan;10(1):170-2. doi: 10.4161/auto.26787. Epub 2013 Nov 11.PMID: 24220263 

2013

eLife and early career researchers.
Schekman R, Watt FM, Weigel D.
Elife. 2013 Oct 22;2:e01633. doi: 10.7554/eLife.01633.PMID: 24156031 

A year in the life of eLife.
Schekman R, Watt FM, Weigel D.
Elife. 2013 Oct 15;2:e01516. doi: 10.7554/eLife.01516.PMID: 24137550 

ALG-2 attenuates COPII budding in vitro and stabilizes the Sec23/Sec31A complex.
la Cour JM, Schindler AJ, Berchtold MW, Schekman R.
PLoS One. 2013 Sep 19;8(9):e75309. doi: 10.1371/journal.pone.0075309. PMID: 24069399 

The structure of the COPII transport-vesicle coat assembled on membranes.
Zanetti G, Prinz S, Daum S, Meister A, Schekman R, Bacia K, Briggs JA.
Elife. 2013 Sep 17;2:e00951. doi: 10.7554/eLife.00951.PMID: 24062940 

Discovery of the cellular and molecular basis of cholesterol control.
Schekman R.
Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14833-6. doi: 10.1073/pnas.1312967110. Epub 2013 Aug 23.PMID: 23975928 

The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis.
Ge L, Melville D, Zhang M, Schekman R.
Elife. 2013 Aug 6;2:e00947. doi: 10.7554/eLife.00947.PMID: 23930225 

COPII - a flexible vesicle formation system.
Miller EA, Schekman R.
Curr Opin Cell Biol. 2013 Aug;25(4):420-7. doi: 10.1016/j.ceb.2013.04.005. Epub 2013 May 20.PMID: 23702145 

Reforming research assessment.
Schekman R, Patterson M.
Elife. 2013 May 16;2:e00855. doi: 10.7554/eLife.00855.PMID: 23700504 

Phosphorylation of Chs2p regulates interaction with COPII.
Jakobsen MK, Cheng Z, Lam SK, Roth-Johnson E, Barfield RM, Schekman R.
J Cell Sci. 2013 May 15;126(Pt 10):2151-6. doi: 10.1242/jcs.115915. Epub 2013 Mar 22.PMID: 23525003 

Cell biology. Unconventional secretion, unconventional solutions.
Zhang M, Schekman R.
Science. 2013 May 3;340(6132):559-61. doi: 10.1126/science.1234740.PMID: 23641104 

The role of the endoplasmic reticulum in peroxisome biogenesis.
Dimitrov L, Lam SK, Schekman R.
Cold Spring Harb Perspect Biol. 2013 May 1;5(5):a013243. doi: 10.1101/cshperspect.a013243.PMID: 23637287 

The eLife approach to peer review.
Schekman R, Watt F, Weigel D.
Elife. 2013 Apr 30;2:e00799. doi: 10.7554/eLife.00799.PMID: 23638304 

SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion.
Chen XW, Wang H, Bajaj K, Zhang P, Meng ZX, Ma D, Bai Y, Liu HH, Adams E, Baines A, Yu G, Sartor MA, Zhang B, Yi Z, Lin J, Young SG, Schekman R, Ginsburg D.
Elife. 2013 Apr 9;2:e00444. doi: 10.7554/eLife.00444.PMID: 23580231 

UNC93B1 mediates differential trafficking of endosomal TLRs.
Lee BL, Moon JE, Shu JH, Yuan L, Newman ZR, Schekman R, Barton GM.
Elife. 2013 Feb 19;2:e00291. doi: 10.7554/eLife.00291.PMID: 23426999 

A novel GTP-binding protein-adaptor protein complex responsible for export of Vangl2 from the trans Golgi network.
Guo Y, Zanetti G, Schekman R.
Elife. 2013 Jan 8;2:e00160. doi: 10.7554/eLife.00160.PMID: 23326640 

2012

Launching eLife, Part 2.
Schekman R, Watt F, Weigel D.
Elife. 2012 Dec 13;1:e00365. doi: 10.7554/eLife.00365.PMID: 23240092 

Launching eLife, Part 1.
Schekman R, Patterson M, Watt F, Weigel D.
Elife. 2012 Oct 15;1:e00270. doi: 10.7554/eLife.00270.PMID: 23066510 

Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans-Golgi network.
Choy RW, Cheng Z, Schekman R.
Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):E2077-82. doi: 10.1073/pnas.1208635109. Epub 2012 Jun 18.PMID: 22711829 

The [corrected] SEC23-SEC31 [corrected] interface plays critical role for export of procollagen from the endoplasmic reticulum.
Kim SD, Pahuja KB, Ravazzola M, Yoon J, Boyadjiev SA, Hammamoto S, Schekman R, Orci L, Kim J.
J Biol Chem. 2012 Mar 23;287(13):10134-10144. doi: 10.1074/jbc.M111.283382. Epub 2012 Feb 1.PMID: 22298774 

Ubiquitin-dependent regulation of COPII coat size and function.
Jin L, Pahuja KB, Wickliffe KE, Gorur A, Baumgärtel C, Schekman R, Rape M.
Nature. 2012 Feb 22;482(7386):495-500. doi: 10.1038/nature10822.PMID: 22358839 

Sec24p and Sec16p cooperate to regulate the GTP cycle of the COPII coat.
Kung LF, Pagant S, Futai E, D'Arcangelo JG, Buchanan R, Dittmar JC, Reid RJ, Rothstein R, Hamamoto S, Snapp EL, Schekman R, Miller EA.
EMBO J. 2012 Feb 15;31(4):1014-27. doi: 10.1038/emboj.2011.444. Epub 2011 Dec 9.PMID: 22157747 

Sorting signals that mediate traffic of chitin synthase III between the TGN/endosomes and to the plasma membrane in yeast.
Starr TL, Pagant S, Wang CW, Schekman R.
PLoS One. 2012;7(10):e46386. doi: 10.1371/journal.pone.0046386. Epub 2012 Oct 3.PMID: 23056294 

2011

COPII and the regulation of protein sorting in mammals.
Zanetti G, Pahuja KB, Studer S, Shim S, Schekman R.
Nat Cell Biol. 2011 Dec 22;14(1):20-8. doi: 10.1038/ncb2390.PMID: 22193160 

Myosin V transports secretory vesicles via a Rab GTPase cascade and interaction with the exocyst complex.
Jin Y, Sultana A, Gandhi P, Franklin E, Hamamoto S, Khan AR, Munson M, Schekman R, Weisman LS.
Dev Cell. 2011 Dec 13;21(6):1156-70. doi: 10.1016/j.devcel.2011.10.009.PMID: 22172676  

Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin.
Zhang B, Zheng C, Zhu M, Tao J, Vasievich MP, Baines A, Kim J, Schekman R, Kaufman RJ, Ginsburg D.
Blood. 2011 Sep 22;118(12):3384-91. doi: 10.1182/blood-2011-05-352815. Epub 2011 Jul 27.PMID: 21795745 

Molecular mechanism of protein folding in the cell.
Rothman JE, Schekman R.
Cell. 2011 Sep 16;146(6):851-4. doi: 10.1016/j.cell.2011.08.041. Epub 2011 Sep 9.PMID: 21907398 

Cranio-lenticulo-sutural dysplasia associated with defects in collagen secretion.
Boyadjiev SA, Kim SD, Hata A, Haldeman-Englert C, Zackai EH, Naydenov C, Hamamoto S, Schekman RW, Kim J.
Clin Genet. 2011 Aug;80(2):169-76. doi: 10.1111/j.1399-0004.2010.01550.x. Epub 2010 Oct 12.PMID: 21039434 

A vesicle carrier that mediates peroxisome protein traffic from the endoplasmic reticulum.
Lam SK, Yoda N, Schekman R.
Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):E51-2. doi: 10.1073/pnas.1103526108.PMID: 21467226 

Multibudded tubules formed by COPII on artificial liposomes.
Bacia K, Futai E, Prinz S, Meister A, Daum S, Glatte D, Briggs JA, Schekman R.
Sci Rep. 2011;1:17. doi: 10.1038/srep00017. Epub 2011 Jun 17.PMID: 22355536 

COPII-mediated vesicle formation at a glance.
Jensen D, Schekman R.
J Cell Sci. 2011 Jan 1;124(Pt 1):1-4. doi: 10.1242/jcs.069773.PMID: 21172817 

2010

A vesicle carrier that mediates peroxisome protein traffic from the endoplasmic reticulum.
Lam SK, Yoda N, Schekman R.
Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21523-8. doi: 10.1073/pnas.1013397107. Epub 2010 Nov 22.PMID: 21098289 

Charting the secretory pathway in a simple eukaryote.
Schekman R.
Mol Biol Cell. 2010 Nov 15;21(22):3781-4. doi: 10.1091/mbc.E10-05-0416.PMID: 21079008 

Patients, patience, and the publication process.
Schekman R.
Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15661. doi: 10.1073/pnas.1012027107. Epub 2010 Aug 23.PMID: 20798042 

Retraction for Liu et al.: Production and secretion of fatty acids in genetically engineered cyanobacteria.
Schekman R.
Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13189. doi: 10.1073/pnas.1008568107. Epub 2010 Jul 2.PMID: 20616067 

Editorial Expression of Concern: A bifunctional tRNA import receptor from Leishmania mitochondria.
Schekman R.
Proc Natl Acad Sci U S A. 2010 May 18;107(20):9476. doi: 10.1073/pnas.1005260107.PMID: 28277630 

Climate change and the integrity of science.
Gleick PH, Adams RM, Amasino RM, Anders E, Anderson DJ, Anderson WW, Anselin LE, Arroyo MK, Asfaw B, Ayala FJ, Bax A, Bebbington AJ, Bell G, Bennett MV, Bennetzen JL, Berenbaum MR, Berlin OB, Bjorkman PJ, Blackburn E, Blamont JE, Botchan MR, Boyer JS, Boyle EA, Branton D, Briggs SP, Briggs WR, Brill WJ, Britten RJ, Broecker WS, Brown JH, Brown PO, Brunger AT, Cairns J Jr, Canfield DE, Carpenter SR, Carrington JC, Cashmore AR, Castilla JC, Cazenave A, Chapin FS 3rd, Ciechanover AJ, Clapham DE, Clark WC, Clayton RN, Coe MD, Conwell EM, Cowling EB, Cowling RM, Cox CS, Croteau RB, Crothers DM, Crutzen PJ, Daily GC, Dalrymple GB, Dangl JL, Darst SA, Davies DR, Davis MB, De Camilli PV, Dean C, DeFries RS, Deisenhofer J, Delmer DP, DeLong EF, DeRosier DJ, Diener TO, Dirzo R, Dixon JE, Donoghue MJ, Doolittle RF, Dunne T, Ehrlich PR, Eisenstadt SN, Eisner T, Emanuel KA, Englander SW, Ernst WG, Falkowski PG, Feher G, Ferejohn JA, Fersht A, Fischer EH, Fischer R, Flannery KV, Frank J, Frey PA, Fridovich I, Frieden C, Futuyma DJ, Gardner WR, Garrett CJ, Gilbert W, Goldberg RB, Goodenough WH, Goodman CS, Goodman M, Greengard P, Hake S, Hammel G, Hanson S, Harrison SC, Hart SR, Hartl DL, Haselk…See abstract for full author list ➔
Science. 2010 May 7;328(5979):689-90. doi: 10.1126/science.328.5979.689.PMID: 20448167 

Editorial expression of concern for Choi et al., Use of combinatorial genetic libraries to humanize N-linked glycosylation in the yeast Pichia pastoris.
Schekman R.
Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7113. doi: 10.1073/pnas.1003237107. Epub 2010 Mar 18.PMID: 20388913 

Editorial Expression of Concern for multiple articles.
Schekman R.
Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6551. doi: 10.1073/pnas.1003210107.PMID: 28277629 

Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure.
Merte J, Jensen D, Wright K, Sarsfield S, Wang Y, Schekman R, Ginty DD.
Nat Cell Biol. 2010 Jan;12(1):41-6; sup pp 1-8. doi: 10.1038/ncb2002. Epub 2009 Dec 6.PMID: 19966784 

2009

The exomer coat complex transports Fus1p to the plasma membrane via a novel plasma membrane sorting signal in yeast.
Barfield RM, Fromme JC, Schekman R.
Mol Biol Cell. 2009 Dec;20(23):4985-96. doi: 10.1091/mbc.e09-04-0324. Epub 2009 Oct 7.PMID: 19812245 

Change is good: life outside the nucleus.
Schekman R.
Nat Cell Biol. 2009 Nov;11(11):1274. doi: 10.1038/ncb1109-1274.PMID: 19884881 

In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles.
Schindler AJ, Schekman R.
Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17775-80. doi: 10.1073/pnas.0910342106. Epub 2009 Oct 12.PMID: 19822759 

Cargo sorting into multivesicular bodies in vitro.
Tran JH, Chen CJ, Emr S, Schekman R.
Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17395-400. doi: 10.1073/pnas.0909473106. Epub 2009 Sep 25.PMID: 19805166 

PNAS takes action regarding breach of NIH embargo policy on a PNAS paper.
Schekman R.
Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):16893. doi: 10.1073/pnas.0910317106. Epub 2009 Sep 18.PMID: 19805088 

Retraction for Venters et al.: A new mechanism of neurodegeneration: a proinflammatory cytokine inhibits receptor signaling by a survival peptide.
Schekman R.
Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13636. doi: 10.1073/pnas.0908052106. Epub 2009 Jul 28.PMID: 19666547 

TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites.
Saito K, Chen M, Bard F, Chen S, Zhou H, Woodley D, Polischuk R, Schekman R, Malhotra V.
Cell. 2009 Mar 6;136(5):891-902. doi: 10.1016/j.cell.2008.12.025.PMID: 19269366 

2008

Retrospective: George E. Palade (1912-2008).
Schekman RW.
Science. 2008 Oct 31;322(5902):695. doi: 10.1126/science.1167174.PMID: 18974342 

Membrane fusion.
Wickner W, Schekman R.
Nat Struct Mol Biol. 2008 Jul;15(7):658-64. doi: 10.1038/nsmb.1451.PMID: 18618939 

Coordination of COPII vesicle trafficking by Sec23.
Fromme JC, Orci L, Schekman R.
Trends Cell Biol. 2008 Jul;18(7):330-6. doi: 10.1016/j.tcb.2008.04.006. Epub 2008 Jun 3.PMID: 18534853 

Role of Sec61p in the ER-associated degradation of short-lived transmembrane proteins.
Scott DC, Schekman R.
J Cell Biol. 2008 Jun 30;181(7):1095-105. doi: 10.1083/jcb.200804053. Epub 2008 Jun 23.PMID: 18573918 

Expression of concern.
Schekman R.
Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7893. doi: 10.1073/pnas.0803900105.PMID: 18584816 

2007

Biogenesis of gamma-secretase early in the secretory pathway.
Kim J, Kleizen B, Choy R, Thinakaran G, Sisodia SS, Schekman RW.
J Cell Biol. 2007 Dec 3;179(5):951-63. doi: 10.1083/jcb.200709012.PMID: 18056412 

The genetic basis of a craniofacial disease provides insight into COPII coat assembly.
Fromme JC, Ravazzola M, Hamamoto S, Al-Balwi M, Eyaid W, Boyadjiev SA, Cosson P, Schekman R, Orci L.
Dev Cell. 2007 Nov;13(5):623-634. doi: 10.1016/j.devcel.2007.10.005.PMID: 17981132 

The bacterial virulence factor NleA inhibits cellular protein secretion by disrupting mammalian COPII function.
Kim J, Thanabalasuriar A, Chaworth-Musters T, Fromme JC, Frey EA, Lario PI, Metalnikov P, Rizg K, Thomas NA, Lee SF, Hartland EL, Hardwidge PR, Pawson T, Strynadka NC, Finlay BB, Schekman R, Gruenheid S.
Cell Host Microbe. 2007 Sep 13;2(3):160-71. doi: 10.1016/j.chom.2007.07.010.PMID: 18005731 

The nine lives of Daniel E. Koshland, Jr. (1920-2007).
Schekman R.
Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14551-2. doi: 10.1073/pnas.0707644104. Epub 2007 Aug 24.PMID: 17720803 

Ent3p and Ent5p exhibit cargo-specific functions in trafficking proteins between the trans-Golgi network and the endosomes in yeast.
Copic A, Starr TL, Schekman R.
Mol Biol Cell. 2007 May;18(5):1803-15. doi: 10.1091/mbc.e06-11-1000. Epub 2007 Mar 7.PMID: 17344475 

How sterols regulate protein sorting and traffic.
Schekman R.
Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6496-7. doi: 10.1073/pnas.0701774104. Epub 2007 Apr 11.PMID: 17428924 

Avl9p, a member of a novel protein superfamily, functions in the late secretory pathway.
Harsay E, Schekman R.
Mol Biol Cell. 2007 Apr;18(4):1203-19. doi: 10.1091/mbc.e06-11-1035. Epub 2007 Jan 17.PMID: 17229886 

2006

QnAs with Randy Schekman. [Interview by Nick Zagorski].
Schekman R.
Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):18881. doi: 10.1073/pnas.0609700103. Epub 2006 Dec 5.PMID: 17148596 

Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking.
Boyadjiev SA, Fromme JC, Ben J, Chong SS, Nauta C, Hur DJ, Zhang G, Hamamoto S, Schekman R, Ravazzola M, Orci L, Eyaid W.
Nat Genet. 2006 Oct;38(10):1192-7. doi: 10.1038/ng1876. Epub 2006 Sep 17.PMID: 16980979

Chs5/6 complex: a multiprotein complex that interacts with and conveys chitin synthase III from the trans-Golgi network to the cell surface.
Sanchatjate S, Schekman R.
Mol Biol Cell. 2006 Oct;17(10):4157-66. doi: 10.1091/mbc.e06-03-0210. Epub 2006 Jul 19.PMID: 16855022 

Exomer: A coat complex for transport of select membrane proteins from the trans-Golgi network to the plasma membrane in yeast.
Wang CW, Hamamoto S, Orci L, Schekman R.
J Cell Biol. 2006 Sep 25;174(7):973-83. doi: 10.1083/jcb.200605106.PMID: 17000877 

2005

Protein translocation across biological membranes.
Wickner W, Schekman R.
Science. 2005 Dec 2;310(5753):1452-6. doi: 10.1126/science.1113752.PMID: 16322447 

Sar1p N-terminal helix initiates membrane curvature and completes the fission of a COPII vesicle.
Lee MC, Orci L, Hamamoto S, Futai E, Ravazzola M, Schekman R.
Cell. 2005 Aug 26;122(4):605-17. doi: 10.1016/j.cell.2005.07.025.PMID: 16122427 

COPII-coated vesicles: flexible enough for large cargo?
Fromme JC, Schekman R.
Curr Opin Cell Biol. 2005 Aug;17(4):345-52. doi: 10.1016/j.ceb.2005.06.004.PMID: 15975775 

ER-Golgi transport defects are associated with mutations in the Sed5p-binding domain of the COPII coat subunit, Sec24p.
Miller EA, Liu Y, Barlowe C, Schekman R.
Mol Biol Cell. 2005 Aug;16(8):3719-26. doi: 10.1091/mbc.e05-03-0262. Epub 2005 Jun 1.PMID: 15930124 

Peroxisomes: another branch of the secretory pathway?
Schekman R.
Cell. 2005 Jul 15;122(1):1-2. doi: 10.1016/j.cell.2005.06.033.PMID: 16009123 

Uncoupled packaging of amyloid precursor protein and presenilin 1 into coat protein complex II vesicles.
Kim J, Hamamoto S, Ravazzola M, Orci L, Schekman R.
J Biol Chem. 2005 Mar 4;280(9):7758-68. doi: 10.1074/jbc.M411091200. Epub 2004 Dec 28.PMID: 15623526 

Interaction of Sla2p's ANTH domain with PtdIns(4,5)P2 is important for actin-dependent endocytic internalization.
Sun Y, Kaksonen M, Madden DT, Schekman R, Drubin DG.
Mol Biol Cell. 2005 Feb;16(2):717-30. doi: 10.1091/mbc.e04-08-0740. Epub 2004 Dec 1.PMID: 15574875 

Purification and functional properties of yeast Sec12 GEF.
Futai E, Schekman R.
Methods Enzymol. 2005;404:74-82. doi: 10.1016/S0076-6879(05)04008-5.PMID: 16413259

2004

Role of Vma21p in assembly and transport of the yeast vacuolar ATPase.
Malkus P, Graham LA, Stevens TH, Schekman R.
Mol Biol Cell. 2004 Nov;15(11):5075-91. doi: 10.1091/mbc.e04-06-0514. Epub 2004 Sep 8.PMID: 15356264 

GTP/GDP exchange by Sec12p enables COPII vesicle bud formation on synthetic liposomes.
Futai E, Hamamoto S, Orci L, Schekman R.
EMBO J. 2004 Oct 27;23(21):4146-55. doi: 10.1038/sj.emboj.7600428. Epub 2004 Sep 30.PMID: 15457212 

Cell biology: a channel for protein waste.
Schekman R.
Nature. 2004 Jun 24;429(6994):817-8. doi: 10.1038/429817a.PMID: 15215847 No abstract available.

Merging cultures in the study of membrane traffic.
Schekman R.
Nat Cell Biol. 2004 Jun;6(6):483-6. doi: 10.1038/ncb0604-483.PMID: 15170459

The ins and outs of presenilin 1 membrane topology.
Kim J, Schekman R.
Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):905-6. doi: 10.1073/pnas.0307297101. Epub 2004 Jan 19.PMID: 14732690 

23 genes, 23 years later.
Schekman R, Novick P.
Cell. 2004 Jan 23;116(2 Suppl):S13-5, 1 p following S19. doi: 10.1016/s0092-8674(03)00972-3.PMID: 15055575 

Cell biology. BAR domains go on a bender.
Lee MC, Schekman R.
Science. 2004 Jan 23;303(5657):479-80. doi: 10.1126/science.1094231.PMID: 14739445 No abstract available.

Bi-directional protein transport between the ER and Golgi.
Lee MC, Miller EA, Goldberg J, Orci L, Schekman R.
Annu Rev Cell Dev Biol. 2004;20:87-123. doi: 10.1146/annurev.cellbio.20.010403.105307.PMID: 15473836 

2003

The yeasts Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane.
Valdivia RH, Schekman R.
Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10287-92. doi: 10.1073/pnas.1834246100. Epub 2003 Aug 19.PMID: 12928491 

Multiple cargo binding sites on the COPII subunit Sec24p ensure capture of diverse membrane proteins into transport vesicles.
Miller EA, Beilharz TH, Malkus PN, Lee MC, Hamamoto S, Orci L, Schekman R.
Cell. 2003 Aug 22;114(4):497-509. doi: 10.1016/s0092-8674(03)00609-3.PMID: 12941277 

Self-assembly of minimal COPII cages.
Antonny B, Gounon P, Schekman R, Orci L.
EMBO Rep. 2003 Apr;4(4):419-24. doi: 10.1038/sj.embor.embor812.PMID: 12671686 

2002

Concentrative sorting of secretory cargo proteins into COPII-coated vesicles.
Malkus P, Jiang F, Schekman R.
J Cell Biol. 2002 Dec 23;159(6):915-21. doi: 10.1083/jcb.200208074. Epub 2002 Dec 23.PMID: 12499351 

Vps10p cycles between the TGN and the late endosome via the plasma membrane in clathrin mutants.
Deloche O, Schekman RW.
Mol Biol Cell. 2002 Dec;13(12):4296-307. doi: 10.1091/mbc.02-07-0105.PMID: 12475953 

Cargo selection into COPII vesicles is driven by the Sec24p subunit.
Miller E, Antonny B, Hamamoto S, Schekman R.
EMBO J. 2002 Nov 15;21(22):6105-13. doi: 10.1093/emboj/cdf605.PMID: 12426382 

Lasker Basic Medical Research Award. SEC mutants and the secretory apparatus.
Schekman R.
Nat Med. 2002 Oct;8(10):1055-8. doi: 10.1038/nm769.PMID: 12357231 

Sec16p potentiates the action of COPII proteins to bud transport vesicles.
Supek F, Madden DT, Hamamoto S, Orci L, Schekman R.
J Cell Biol. 2002 Sep 16;158(6):1029-38. doi: 10.1083/jcb.200207053. Epub 2002 Sep 16.PMID: 12235121

Ceramide biosynthesis is required for the formation of the oligomeric H+-ATPase Pma1p in the yeast endoplasmic reticulum.
Lee MC, Hamamoto S, Schekman R.
J Biol Chem. 2002 Jun 21;277(25):22395-401. doi: 10.1074/jbc.M200450200. Epub 2002 Apr 11.PMID: 11950838 

The yeast clathrin adaptor protein complex 1 is required for the efficient retention of a subset of late Golgi membrane proteins.
Valdivia RH, Baggott D, Chuang JS, Schekman RW.
Dev Cell. 2002 Mar;2(3):283-94. doi: 10.1016/s1534-5807(02)00127-2.PMID: 11879634 

A subset of yeast vacuolar protein sorting mutants is blocked in one branch of the exocytic pathway.
Harsay E, Schekman R.
J Cell Biol. 2002 Jan 21;156(2):271-85. doi: 10.1083/jcb.200109077. Epub 2002 Jan 21.PMID: 11807092 

Vesicle budding from endoplasmic reticulum.
Shimoni Y, Schekman R.
Methods Enzymol. 2002;351:258-78. doi: 10.1016/s0076-6879(02)51852-8.PMID: 12073349 

2001

Surface structure of the COPII-coated vesicle.
Matsuoka K, Schekman R, Orci L, Heuser JE.
Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13705-9. doi: 10.1073/pnas.241522198.PMID: 11717432 

Structure of the Sec23p/24p and Sec13p/31p complexes of COPII.
Lederkremer GZ, Cheng Y, Petre BM, Vogan E, Springer S, Schekman R, Walz T, Kirchhausen T.
Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10704-9. doi: 10.1073/pnas.191359398. Epub 2001 Sep 4.PMID: 11535824 

ER export: public transportation by the COPII coach.
Antonny B, Schekman R.
Curr Opin Cell Biol. 2001 Aug;13(4):438-43. doi: 10.1016/s0955-0674(00)00234-9.PMID: 11454450 

Dynamics of the COPII coat with GTP and stable analogues.
Antonny B, Madden D, Hamamoto S, Orci L, Schekman R.
Nat Cell Biol. 2001 Jun;3(6):531-7. doi: 10.1038/35078500.PMID: 11389436

The ADP ribosylation factor-nucleotide exchange factors Gea1p and Gea2p have overlapping, but not redundant functions in retrograde transport from the Golgi to the endoplasmic reticulum.
Spang A, Herrmann JM, Hamamoto S, Schekman R.
Mol Biol Cell. 2001 Apr;12(4):1035-45. doi: 10.1091/mbc.12.4.1035.PMID: 11294905 

Vps10p transport from the trans-Golgi network to the endosome is mediated by clathrin-coated vesicles.
Deloche O, Yeung BG, Payne GS, Schekman R.
Mol Biol Cell. 2001 Feb;12(2):475-85. doi: 10.1091/mbc.12.2.475.PMID: 11179429 

2000

Active recycling of yeast Golgi mannosyltransferase complexes through the endoplasmic reticulum.
Todorow Z, Spang A, Carmack E, Yates J, Schekman R.
Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13643-8. doi: 10.1073/pnas.250472397.PMID: 11095735 

Lst1p and Sec24p cooperate in sorting of the plasma membrane ATPase into COPII vesicles in Saccharomyces cerevisiae.
Shimoni Y, Kurihara T, Ravazzola M, Amherdt M, Orci L, Schekman R.
J Cell Biol. 2000 Nov 27;151(5):973-84. doi: 10.1083/jcb.151.5.973.PMID: 11086000 

The p24 proteins are not essential for vesicular transport in Saccharomyces cerevisiae.
Springer S, Chen E, Duden R, Marzioch M, Rowley A, Hamamoto S, Merchant S, Schekman R.
Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4034-9. doi: 10.1073/pnas.070044097.PMID: 10737764 

The use of liposomes to study COPII- and COPI-coated vesicle formation and membrane protein sorting.
Matsuoka K, Schekman R.
Methods. 2000 Apr;20(4):417-28. doi: 10.1006/meth.2000.0955.PMID: 10720463

Sec24p and Iss1p function interchangeably in transport vesicle formation from the endoplasmic reticulum in Saccharomyces cerevisiae.
Kurihara T, Hamamoto S, Gimeno RE, Kaiser CA, Schekman R, Yoshihisa T.
Mol Biol Cell. 2000 Mar;11(3):983-98. doi: 10.1091/mbc.11.3.983.PMID: 10712514 

Pho86p, an endoplasmic reticulum (ER) resident protein in Saccharomyces cerevisiae, is required for ER exit of the high-affinity phosphate transporter Pho84p.
Lau WT, Howson RW, Malkus P, Schekman R, O'Shea EK.
Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1107-12. doi: 10.1073/pnas.97.3.1107.PMID: 10655492 

1999

The engagement of Sec61p in the ER dislocation process.
Zhou M, Schekman R.
Mol Cell. 1999 Dec;4(6):925-34. doi: 10.1016/s1097-2765(00)80222-1.PMID: 10635318 

Protein translocation: how Hsp70 pulls it off.
Pilon M, Schekman R.
Cell. 1999 Jun 11;97(6):679-82. doi: 10.1016/s0092-8674(00)80780-1.PMID: 10380919 

A primer on vesicle budding.
Springer S, Spang A, Schekman R.
Cell. 1999 Apr 16;97(2):145-8. doi: 10.1016/s0092-8674(00)80722-9.PMID: 10219233 

Out of the ER--outfitters, escorts and guides.
Herrmann JM, Malkus P, Schekman R.
Trends Cell Biol. 1999 Jan;9(1):5-7. doi: 10.1016/s0962-8924(98)01414-7.PMID: 10087610 

1998

Membrane fusion. Ready...aim...fire!
Schekman R.
Nature. 1998 Dec 10;396(6711):514-5. doi: 10.1038/24986.PMID: 9859980 

Sec61p serves multiple roles in secretory precursor binding and translocation into the endoplasmic reticulum membrane.
Pilon M, Römisch K, Quach D, Schekman R.
Mol Biol Cell. 1998 Dec;9(12):3455-73. doi: 10.1091/mbc.9.12.3455.PMID: 9843581 

Reconstitution of retrograde transport from the Golgi to the ER in vitro.
Spang A, Schekman R.
J Cell Biol. 1998 Nov 2;143(3):589-99. doi: 10.1083/jcb.143.3.589.PMID: 9813082 

Coat assembly directs v-SNARE concentration into synthetic COPII vesicles.
Matsuoka K, Morimitsu Y, Uchida K, Schekman R.
Mol Cell. 1998 Nov;2(5):703-8. doi: 10.1016/s1097-2765(00)80168-9.PMID: 9844642 

Coatomer, Arf1p, and nucleotide are required to bud coat protein complex I-coated vesicles from large synthetic liposomes.
Spang A, Matsuoka K, Hamamoto S, Schekman R, Orci L.
Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11199-204. doi: 10.1073/pnas.95.19.11199.PMID: 9736713 

Nucleation of COPII vesicular coat complex by endoplasmic reticulum to Golgi vesicle SNAREs.
Springer S, Schekman R.
Science. 1998 Jul 31;281(5377):698-700. doi: 10.1126/science.281.5377.698.PMID: 9685263

Chs6p-dependent anterograde transport of Chs3p from the chitosome to the plasma membrane in Saccharomyces cerevisiae.
Ziman M, Chuang JS, Tsung M, Hamamoto S, Schekman R.
Mol Biol Cell. 1998 Jun;9(6):1565-76. doi: 10.1091/mbc.9.6.1565.PMID: 9614194 

COPII-coated vesicle formation reconstituted with purified coat proteins and chemically defined liposomes.
Matsuoka K, Orci L, Amherdt M, Bednarek SY, Hamamoto S, Schekman R, Yeung T.
Cell. 1998 Apr 17;93(2):263-75. doi: 10.1016/s0092-8674(00)81577-9.PMID: 9568718 

epsilon-COP is a structural component of coatomer that functions to stabilize alpha-COP.
Duden R, Kajikawa L, Wuestehube L, Schekman R.
EMBO J. 1998 Feb 16;17(4):985-95. doi: 10.1093/emboj/17.4.985.PMID: 9463377 

COPII-cargo interactions direct protein sorting into ER-derived transport vesicles.
Kuehn MJ, Herrmann JM, Schekman R.
Nature. 1998 Jan 8;391(6663):187-90. doi: 10.1038/34438.PMID: 9428766

1997

Glycosyl-phosphatidylinositol anchor attachment in a yeast in vitro system.
Doering TL, Schekman R.
Biochem J. 1997 Dec 1;328 ( Pt 2)(Pt 2):669-75. doi: 10.1042/bj3280669.PMID: 9371730 

Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation.
Pilon M, Schekman R, Römisch K.
EMBO J. 1997 Aug 1;16(15):4540-8. doi: 10.1093/emboj/16.15.4540.PMID: 9303298 

COPII and secretory cargo capture into transport vesicles.
Kuehn MJ, Schekman R.
Curr Opin Cell Biol. 1997 Aug;9(4):477-83. doi: 10.1016/s0955-0674(97)80022-1.PMID: 9261052 

Does COPI go both ways?
Schekman R, Mellman I.
Cell. 1997 Jul 25;90(2):197-200. doi: 10.1016/s0092-8674(00)80326-8.PMID: 9244292 

The lumenal domain of Sec63p stimulates the ATPase activity of BiP and mediates BiP recruitment to the translocon in Saccharomyces cerevisiae.
Corsi AK, Schekman R.
J Cell Biol. 1997 Jun 30;137(7):1483-93. doi: 10.1083/jcb.137.7.1483.PMID: 9199165 

Selective packaging of cargo molecules into endoplasmic reticulum-derived COPII vesicles.
Campbell JL, Schekman R.
Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):837-42. doi: 10.1073/pnas.94.3.837.PMID: 9023343 

Sec31 encodes an essential component of the COPII coat required for transport vesicle budding from the endoplasmic reticulum.
Salama NR, Chuang JS, Schekman RW.
Mol Biol Cell. 1997 Feb;8(2):205-17. doi: 10.1091/mbc.8.2.205.PMID: 9190202 

Binding of secretory precursor polypeptides to a translocon subcomplex is regulated by BiP.
Lyman SK, Schekman R.
Cell. 1997 Jan 10;88(1):85-96. doi: 10.1016/s0092-8674(00)81861-9.PMID: 9019409 

1996

Polypeptide translocation machinery of the yeast endoplasmic reticulum.
Lyman SK, Schekman R.
Experientia. 1996 Dec 15;52(12):1042-9. doi: 10.1007/BF01952100.PMID: 8988244 

Traffic COPs and the formation of vesicle coats.
Bednarek SY, Orci L, Schekman R.
Trends Cell Biol. 1996 Dec;6(12):468-73. doi: 10.1016/0962-8924(96)84943-9.PMID: 15157504

Chs1p and Chs3p, two proteins involved in chitin synthesis, populate a compartment of the Saccharomyces cerevisiae endocytic pathway.
Ziman M, Chuang JS, Schekman RW.
Mol Biol Cell. 1996 Dec;7(12):1909-19. doi: 10.1091/mbc.7.12.1909.PMID: 8970154 

Mechanism of polypeptide translocation into the endoplasmic reticulum.
Corsi AK, Schekman R.
J Biol Chem. 1996 Nov 29;271(48):30299-302. doi: 10.1074/jbc.271.48.30299.PMID: 8939984 

Polypeptide translocation: a pretty picture is worth a thousand words.
Schekman R.
Cell. 1996 Nov 15;87(4):593-5. doi: 10.1016/s0092-8674(00)81378-1.PMID: 8929528 

Differential trafficking and timed localization of two chitin synthase proteins, Chs2p and Chs3p.
Chuang JS, Schekman RW.
J Cell Biol. 1996 Nov;135(3):597-610. doi: 10.1083/jcb.135.3.597.PMID: 8909536 

Amino acid permeases require COPII components and the ER resident membrane protein Shr3p for packaging into transport vesicles in vitro.
Kuehn MJ, Schekman R, Ljungdahl PO.
J Cell Biol. 1996 Nov;135(3):585-95. doi: 10.1083/jcb.135.3.585.PMID: 8909535 

Cloning and functional characterization of mammalian homologues of the COPII component Sec23.
Paccaud JP, Reith W, Carpentier JL, Ravazzola M, Amherdt M, Schekman R, Orci L.
Mol Biol Cell. 1996 Oct;7(10):1535-46. doi: 10.1091/mbc.7.10.1535.PMID: 8898360 

Interleaflet clear space is reduced in the membrane of COP I and COP II-coated buds/vesicles.
Orci L, Schekman R, Perrelet A.
Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):8968-70. doi: 10.1073/pnas.93.17.8968.PMID: 8799137 

Selective uptake of cytosolic, peroxisomal, and plasma membrane proteins into the yeast lysosome for degradation.
Chiang HL, Schekman R, Hamamoto S.
J Biol Chem. 1996 Apr 26;271(17):9934-41. doi: 10.1074/jbc.271.17.9934.PMID: 8626630 

Coat proteins and vesicle budding.
Schekman R, Orci L.
Science. 1996 Mar 15;271(5255):1526-33. doi: 10.1126/science.271.5255.1526.PMID: 8599108 

New mutants of Saccharomyces cerevisiae affected in the transport of proteins from the endoplasmic reticulum to the Golgi complex.
Wuestehube LJ, Duden R, Eun A, Hamamoto S, Korn P, Ram R, Schekman R.
Genetics. 1996 Feb;142(2):393-406. doi: 10.1093/genetics/142.2.393.PMID: 8852839 

Biochemical requirements for the targeting and fusion of ER-derived transport vesicles with purified yeast Golgi membranes.
Lupashin VV, Hamamoto S, Schekman RW.
J Cell Biol. 1996 Feb;132(3):277-89. doi: 10.1083/jcb.132.3.277.PMID: 8636207 

GPI anchor attachment is required for Gas1p transport from the endoplasmic reticulum in COP II vesicles.
Doering TL, Schekman R.
EMBO J. 1996 Jan 2;15(1):182-91.PMID: 8598201 

1995

COPI- and COPII-coated vesicles bud directly from the endoplasmic reticulum in yeast.
Bednarek SY, Ravazzola M, Hosobuchi M, Amherdt M, Perrelet A, Schekman R, Orci L.
Cell. 1995 Dec 29;83(7):1183-96. doi: 10.1016/0092-8674(95)90144-2.PMID: 8548805 

Uncoupled packaging of targeting and cargo molecules during transport vesicle budding from the endoplasmic reticulum.
Yeung T, Barlowe C, Schekman R.
J Biol Chem. 1995 Dec 22;270(51):30567-70. doi: 10.1074/jbc.270.51.30567.PMID: 8530490  

Interaction between BiP and Sec63p is required for the completion of protein translocation into the ER of Saccharomyces cerevisiae.
Lyman SK, Schekman R.
J Cell Biol. 1995 Dec;131(5):1163-71. doi: 10.1083/jcb.131.5.1163.PMID: 8522580 

BiP and Sec63p are required for both co- and posttranslational protein translocation into the yeast endoplasmic reticulum.
Brodsky JL, Goeckeler J, Schekman R.
Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9643-6. doi: 10.1073/pnas.92.21.9643.PMID: 7568189 

Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes.
Latterich M, Fröhlich KU, Schekman R.
Cell. 1995 Sep 22;82(6):885-93. doi: 10.1016/0092-8674(95)90268-6.PMID: 7553849 

The role of coat proteins in the biosynthesis of secretory proteins.
Salama NR, Schekman RW.
Curr Opin Cell Biol. 1995 Aug;7(4):536-43. doi: 10.1016/0955-0674(95)80011-5.PMID: 7495574 

Coat proteins and selective protein packaging into transport vesicles.
Schekman R, Barlowe C, Bednarek S, Campbell J, Doering T, Duden R, Kuehn M, Rexach M, Yeung T, Orci L.
Cold Spring Harb Symp Quant Biol. 1995;60:11-21. doi: 10.1101/sqb.1995.060.01.004.PMID: 8824373 

Expression, purification, and assay of Sec12p: a Sar1p-specific GDP dissociation stimulator.
Barlowe C, Schekman R.
Methods Enzymol. 1995;257:98-106. doi: 10.1016/s0076-6879(95)57015-2.PMID: 8583945 

Purification of Sec23p-Sec24p complex.
Yeung T, Yoshihisa T, Schekman R.
Methods Enzymol. 1995;257:145-51. doi: 10.1016/s0076-6879(95)57020-9.PMID: 8583916 

1994

Coatomer-rich endoplasmic reticulum.
Orci L, Perrelet A, Ravazzola M, Amherdt M, Rothman JE, Schekman R.
Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11924-8. doi: 10.1073/pnas.91.25.11924.PMID: 7991558 

SSS1 encodes a stabilizing component of the Sec61 subcomplex of the yeast protein translocation apparatus.
Esnault Y, Feldheim D, Blondel MO, Schekman R, Képès F.
J Biol Chem. 1994 Nov 4;269(44):27478-85.PMID: 7961662 

Yeast beta- and beta'-coat proteins (COP). Two coatomer subunits essential for endoplasmic reticulum-to-Golgi protein traffic.
Duden R, Hosobuchi M, Hamamoto S, Winey M, Byers B, Schekman R.
J Biol Chem. 1994 Sep 30;269(39):24486-95.PMID: 7929113 

Translocation gets a push.
Schekman R.
Cell. 1994 Sep 23;78(6):911-3. doi: 10.1016/0092-8674(94)90265-8.PMID: 7923360 

Characteristics of endoplasmic reticulum-derived transport vesicles.
Rexach MF, Latterich M, Schekman RW.
J Cell Biol. 1994 Sep;126(5):1133-48. doi: 10.1083/jcb.126.5.1133.PMID: 8063853 

Sec72p contributes to the selective recognition of signal peptides by the secretory polypeptide translocation complex.
Feldheim D, Schekman R.
J Cell Biol. 1994 Aug;126(4):935-43. doi: 10.1083/jcb.126.4.935.PMID: 8051213 

Nuclear congression and membrane fusion: two distinct events in the yeast karyogamy pathway.
Kurihara LJ, Beh CT, Latterich M, Schekman R, Rose MD.
J Cell Biol. 1994 Aug;126(4):911-23. doi: 10.1083/jcb.126.4.911.PMID: 8051211 

The karyogamy gene KAR2 and novel proteins are required for ER-membrane fusion.
Latterich M, Schekman R.
Cell. 1994 Jul 15;78(1):87-98. doi: 10.1016/0092-8674(94)90575-4.PMID: 8033215

COPII: a membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum.
Barlowe C, Orci L, Yeung T, Hosobuchi M, Hamamoto S, Salama N, Rexach MF, Ravazzola M, Amherdt M, Schekman R.
Cell. 1994 Jun 17;77(6):895-907. doi: 10.1016/0092-8674(94)90138-4.PMID: 8004676

Regulation of membrane traffic in the secretory pathway.
Schekman RW.
Harvey Lect. 1994-1995;90:41-57.PMID: 8803318

1993

A Sec63p-BiP complex from yeast is required for protein translocation in a reconstituted proteoliposome.
Brodsky JL, Schekman R.
J Cell Biol. 1993 Dec;123(6 Pt 1):1355-63. doi: 10.1083/jcb.123.6.1355.PMID: 8253836 

"BFA bodies": a subcompartment of the endoplasmic reticulum.
Orci L, Perrelet A, Ravazzola M, Wieland FT, Schekman R, Rothman JE.
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11089-93. doi: 10.1073/pnas.90.23.11089.PMID: 8248213 

The Sec13p complex and reconstitution of vesicle budding from the ER with purified cytosolic proteins.
Salama NR, Yeung T, Schekman RW.
EMBO J. 1993 Nov;12(11):4073-82. doi: 10.1002/j.1460-2075.1993.tb06091.x.PMID: 8223424 

SEC12 encodes a guanine-nucleotide-exchange factor essential for transport vesicle budding from the ER.
Barlowe C, Schekman R.
Nature. 1993 Sep 23;365(6444):347-9. doi: 10.1038/365347a0.PMID: 8377826

Structural and functional characterization of Sec66p, a new subunit of the polypeptide translocation apparatus in the yeast endoplasmic reticulum.
Feldheim D, Yoshimura K, Admon A, Schekman R.
Mol Biol Cell. 1993 Sep;4(9):931-9. doi: 10.1091/mbc.4.9.931.PMID: 8257795 

Requirement for a GTPase-activating protein in vesicle budding from the endoplasmic reticulum.
Yoshihisa T, Barlowe C, Schekman R.
Science. 1993 Mar 5;259(5100):1466-8. doi: 10.1126/science.8451644.PMID: 8451644

Cytosolic Sec13p complex is required for vesicle formation from the endoplasmic reticulum in vitro.
Pryer NK, Salama NR, Schekman R, Kaiser CA.
J Cell Biol. 1993 Feb;120(4):865-75. doi: 10.1083/jcb.120.4.865.PMID: 8432727 

Purification and characterization of SAR1p, a small GTP-binding protein required for transport vesicle formation from the endoplasmic reticulum.
Barlowe C, d'Enfert C, Schekman R.
J Biol Chem. 1993 Jan 15;268(2):873-9.PMID: 8419365 

Reconstitution of protein translocation from solubilized yeast membranes reveals topologically distinct roles for BiP and cytosolic Hsc70.
Brodsky JL, Hamamoto S, Feldheim D, Schekman R.
J Cell Biol. 1993 Jan;120(1):95-102. doi: 10.1083/jcb.120.1.95.PMID: 8416998 

1992

SEC21 is a gene required for ER to Golgi protein transport that encodes a subunit of a yeast coatomer.
Hosobuchi M, Kreis T, Schekman R.
Nature. 1992 Dec 10;360(6404):603-5. doi: 10.1038/360603a0.PMID: 1461285

Distinct processes mediate glycoprotein and glycopeptide export from the endoplasmic reticulum in Saccharomyces cerevisiae.
Römisch K, Schekman R.
Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7227-31. doi: 10.1073/pnas.89.15.7227.PMID: 1496016 

Genetic and biochemical analysis of vesicular traffic in yeast.
Schekman R.
Curr Opin Cell Biol. 1992 Aug;4(4):587-92. doi: 10.1016/0955-0674(92)90076-o.PMID: 1419039 

Polypeptide translocation across the endoplasmic reticulum membrane.
Sanders SL, Schekman R.
J Biol Chem. 1992 Jul 15;267(20):13791-4.PMID: 1321124

Topology and functional domains of Sec63p, an endoplasmic reticulum membrane protein required for secretory protein translocation.
Feldheim D, Rothblatt J, Schekman R.
Mol Cell Biol. 1992 Jul;12(7):3288-96. doi: 10.1128/mcb.12.7.3288-3296.1992.PMID: 1620130 

The yeast SEC17 gene product is functionally equivalent to mammalian alpha-SNAP protein.
Griff IC, Schekman R, Rothman JE, Kaiser CA.
J Biol Chem. 1992 Jun 15;267(17):12106-15.PMID: 1601878 

Sec23p and a novel 105-kDa protein function as a multimeric complex to promote vesicle budding and protein transport from the endoplasmic reticulum.
Hicke L, Yoshihisa T, Schekman R.
Mol Biol Cell. 1992 Jun;3(6):667-76. doi: 10.1091/mbc.3.6.667.PMID: 1498369 

Sec61p and BiP directly facilitate polypeptide translocation into the ER.
Sanders SL, Whitfield KM, Vogel JP, Rose MD, Schekman RW.
Cell. 1992 Apr 17;69(2):353-65. doi: 10.1016/0092-8674(92)90415-9.PMID: 1568250

Genes and proteins required for vesicular transport from the endoplasmic reticulum.
Rexach M, d'Enfert C, Wuestehube L, Schekman R.
Antonie Van Leeuwenhoek. 1992 Feb;61(2):87-92. doi: 10.1007/BF00580612.PMID: 1580619 

Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulum.
Stirling CJ, Rothblatt J, Hosobuchi M, Deshaies R, Schekman R.
Mol Biol Cell. 1992 Feb;3(2):129-42. doi: 10.1091/mbc.3.2.129.PMID: 1550957 

Vesicle-mediated protein sorting.
Pryer NK, Wuestehube LJ, Schekman R.
Annu Rev Biochem. 1992;61:471-516. doi: 10.1146/annurev.bi.61.070192.002351.PMID: 1497318 

Purification of yeast Sec23 protein by complementation of mutant cell lysates deficient in endoplasmic reticulum-to-Golgi transport.
Hicke L, Yoshihisa T, Schekman RW.
Methods Enzymol. 1992;219:338-52. doi: 10.1016/0076-6879(92)19034-4.PMID: 1488007 

Use of sec mutants to define intermediates in protein transport from endoplasmic reticulum.
Rexach MF, Schekman RW.
Methods Enzymol. 1992;219:267-86. doi: 10.1016/0076-6879(92)19028-5.PMID: 1488000

Reconstitution of transport from endoplasmic reticulum to Golgi complex using endoplasmic reticulum-enriched membrane fraction from yeast.
Wuestehube LJ, Schekman RW.
Methods Enzymol. 1992;219:124-36. doi: 10.1016/0076-6879(92)19015-x.PMID: 1487986

1991

Structural and functional dissection of a membrane glycoprotein required for vesicle budding from the endoplasmic reticulum.
d'Enfert C, Barlowe C, Nishikawa S, Nakano A, Schekman R.
Mol Cell Biol. 1991 Nov;11(11):5727-34. doi: 10.1128/mcb.11.11.5727-5734.1991.PMID: 1922074

Mammalian Sec23p homologue is restricted to the endoplasmic reticulum transitional cytoplasm.
Orci L, Ravazzola M, Meda P, Holcomb C, Moore HP, Hicke L, Schekman R.
Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8611-5. doi: 10.1073/pnas.88.19.8611.PMID: 1924322

Sec12p-dependent membrane binding of the small GTP-binding protein Sar1p promotes formation of transport vesicles from the ER.
d'Enfert C, Wuestehube LJ, Lila T, Schekman R.
J Cell Biol. 1991 Aug;114(4):663-70. doi: 10.1083/jcb.114.4.663.PMID: 1907973 

Distinct biochemical requirements for the budding, targeting, and fusion of ER-derived transport vesicles.
Rexach MF, Schekman RW.
J Cell Biol. 1991 Jul;114(2):219-29. doi: 10.1083/jcb.114.2.219.PMID: 1649197 

Regulated import and degradation of a cytosolic protein in the yeast vacuole.
Chiang HL, Schekman R.
Nature. 1991 Mar 28;350(6316):313-8. doi: 10.1038/350313a0.PMID: 1848921

Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex.
Deshaies RJ, Sanders SL, Feldheim DA, Schekman R.
Nature. 1991 Feb 28;349(6312):806-8. doi: 10.1038/349806a0.PMID: 2000150

Analysis of polypeptide transit through yeast secretory pathway.
Franzusoff A, Rothblatt J, Schekman R.
Methods Enzymol. 1991;194:662-74. doi: 10.1016/0076-6879(91)94048-h.PMID: 2005814 

Localization of components involved in protein transport and processing through the yeast Golgi apparatus.
Franzusoff A, Redding K, Crosby J, Fuller RS, Schekman R.
J Cell Biol. 1991 Jan;112(1):27-37. doi: 10.1083/jcb.112.1.27.PMID: 1986005 

1990

Structural and functional dissection of Sec62p, a membrane-bound component of the yeast endoplasmic reticulum protein import machinery.
Deshaies RJ, Schekman R.
Mol Cell Biol. 1990 Nov;10(11):6024-35. doi: 10.1128/mcb.10.11.6024-6035.1990.PMID: 2233730

Yeast clathrin has a distinctive light chain that is important for cell growth.
Silveira LA, Wong DH, Masiarz FR, Schekman R.
J Cell Biol. 1990 Oct;111(4):1437-49. doi: 10.1083/jcb.111.4.1437.PMID: 2211819 

Molecular machinery required for protein transport from the endoplasmic reticulum to the Golgi complex.
Hicke L, Schekman R.
Bioessays. 1990 Jun;12(6):253-8. doi: 10.1002/bies.950120602.PMID: 2117453 

Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway.
Kaiser CA, Schekman R.
Cell. 1990 May 18;61(4):723-33. doi: 10.1016/0092-8674(90)90483-u.PMID: 2188733

Genetic and biochemical evaluation of eucaryotic membrane protein topology: multiple transmembrane domains of Saccharomyces cerevisiae 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Sengstag C, Stirling C, Schekman R, Rine J.
Mol Cell Biol. 1990 Feb;10(2):672-80. doi: 10.1128/mcb.10.2.672-680.1990.PMID: 2405252 

GTP-binding Ypt1 protein and Ca2+ function independently in a cell-free protein transport reaction.
Baker D, Wuestehube L, Schekman R, Botstein D, Segev N.
Proc Natl Acad Sci U S A. 1990 Jan;87(1):355-9. doi: 10.1073/pnas.87.1.355.PMID: 2104983

1989 

SEC62 encodes a putative membrane protein required for protein translocation into the yeast endoplasmic reticulum.
Deshaies RJ, Schekman R.
J Cell Biol. 1989 Dec;109(6 Pt 1):2653-64. doi: 10.1083/jcb.109.6.2653.PMID: 2687286 

Multiple genes are required for proper insertion of secretory proteins into the endoplasmic reticulum in yeast.
Rothblatt JA, Deshaies RJ, Sanders SL, Daum G, Schekman R.
J Cell Biol. 1989 Dec;109(6 Pt 1):2641-52. doi: 10.1083/jcb.109.6.2641.PMID: 2687285 

Clathrin: a role in the intracellular retention of a Golgi membrane protein.
Payne GS, Schekman R.
Science. 1989 Sep 22;245(4924):1358-65. doi: 10.1126/science.2675311.PMID: 2675311

Functional compartments of the yeast Golgi apparatus are defined by the sec7 mutation.
Franzusoff A, Schekman R.
EMBO J. 1989 Sep;8(9):2695-702. doi: 10.1002/j.1460-2075.1989.tb08410.x.PMID: 2684655 

Yeast Sec23p acts in the cytoplasm to promote protein transport from the endoplasmic reticulum to the Golgi complex in vivo and in vitro.
Hicke L, Schekman R.
EMBO J. 1989 Jun;8(6):1677-84. doi: 10.1002/j.1460-2075.1989.tb03559.x.PMID: 2670558 

Sec59 encodes a membrane protein required for core glycosylation in Saccharomyces cerevisiae.
Bernstein M, Kepes F, Schekman R.
Mol Cell Biol. 1989 Mar;9(3):1191-9. doi: 10.1128/mcb.9.3.1191-1199.1989.PMID: 2657387 

A hitchhiker's guide to analysis of the secretory pathway in yeast.
Rothblatt J, Schekman R.
Methods Cell Biol. 1989;32:3-36. doi: 10.1016/s0091-679x(08)61165-6.PMID: 2691854 

Reconstitution of protein transport using broken yeast spheroplasts.
Baker D, Schekman R.
Methods Cell Biol. 1989;31:127-41. doi: 10.1016/s0091-679x(08)61605-2.PMID: 2674623 

1988

The role of stress proteins in membrane biogenesis.
Deshaies RJ, Koch BD, Schekman R.
Trends Biochem Sci. 1988 Oct;13(10):384-8. doi: 10.1016/0968-0004(88)90180-6.PMID: 3072700 

A membrane glycoprotein, Sec12p, required for protein transport from the endoplasmic reticulum to the Golgi apparatus in yeast.
Nakano A, Brada D, Schekman R.
J Cell Biol. 1988 Sep;107(3):851-63. doi: 10.1083/jcb.107.3.851.PMID: 3047151 

SEC7 encodes an unusual, high molecular weight protein required for membrane traffic from the yeast Golgi apparatus.
Achstetter T, Franzusoff A, Field C, Schekman R.
J Biol Chem. 1988 Aug 25;263(24):11711-7.PMID: 3042778 

Reconstitution of SEC gene product-dependent intercompartmental protein transport.
Baker D, Hicke L, Rexach M, Schleyer M, Schekman R.
Cell. 1988 Jul 29;54(3):335-44. doi: 10.1016/0092-8674(88)90196-1.PMID: 3293799

The yeast SEC53 gene encodes phosphomannomutase.
Kepes F, Schekman R.
J Biol Chem. 1988 Jul 5;263(19):9155-61.PMID: 3288631 

Coincident localization of secretory and plasma membrane proteins in organelles of the yeast secretory pathway.
Brada D, Schekman R.
J Bacteriol. 1988 Jun;170(6):2775-83. doi: 10.1128/jb.170.6.2775-2783.1988.PMID: 2967284 

Protein transport to the vacuole and receptor-mediated endocytosis by clathrin heavy chain-deficient yeast.
Payne GS, Baker D, van Tuinen E, Schekman R.
J Cell Biol. 1988 May;106(5):1453-61. doi: 10.1083/jcb.106.5.1453.PMID: 2836429 

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides.
Deshaies RJ, Koch BD, Werner-Washburne M, Craig EA, Schekman R.
Nature. 1988 Apr 28;332(6167):800-5. doi: 10.1038/332800a0.PMID: 3282178

SEC11 is required for signal peptide processing and yeast cell growth.
Böhni PC, Deshaies RJ, Schekman RW.
J Cell Biol. 1988 Apr;106(4):1035-42. doi: 10.1083/jcb.106.4.1035.PMID: 3283143 

Secretory vesicles externalize the major plasma membrane ATPase in yeast.
Holcomb CL, Hansen WJ, Etcheverry T, Schekman R.
J Cell Biol. 1988 Mar;106(3):641-8. doi: 10.1083/jcb.106.3.641.PMID: 2964451 

Clathrin: a matter of life or death?
Schekman R, Payne G.
Science. 1988 Feb 19;239(4842):919. doi: 10.1126/science.3277285.PMID: 3277285 

1987

Isolation of secretory vesicles from Saccharomyces cerevisiae.
Holcomb CL, Etcheverry T, Schekman R.
Anal Biochem. 1987 Nov 1;166(2):328-34. doi: 10.1016/0003-2697(87)90581-1.PMID: 3324821

Genetic and biochemical characterization of clathrin-deficient Saccharomyces cerevisiae.
Payne GS, Hasson TB, Hasson MS, Schekman R.
Mol Cell Biol. 1987 Nov;7(11):3888-98. doi: 10.1128/mcb.7.11.3888-3898.1987.PMID: 3323882 

A yeast mutant defective at an early stage in import of secretory protein precursors into the endoplasmic reticulum.
Deshaies RJ, Schekman R.
J Cell Biol. 1987 Aug;105(2):633-45. doi: 10.1083/jcb.105.2.633.PMID: 3305520 

Product of SEC53 is required for folding and glycosylation of secretory proteins in the lumen of the yeast endoplasmic reticulum.
Feldman RI, Bernstein M, Schekman R.
J Biol Chem. 1987 Jul 5;262(19):9332-9.PMID: 3298255 

Structure, assembly, and secretion of octameric invertase.
Esmon PC, Esmon BE, Schauer IE, Taylor A, Schekman R.
J Biol Chem. 1987 Mar 25;262(9):4387-94.PMID: 3031075 

1986

41. Gene dosage-dependent secretion of yeast vacuolar carboxypeptidase Y.
Stevens TH, Rothman JH, Payne GS, Schekman R.
J Cell Biol. 1986 May;102(5):1551-7. doi: 10.1083/jcb.102.5.1551. PMID: 3517002. 

40. GAL2 codes for a membrane-bound subunit of the galactose permease in Saccharomyces cerevisiae.
Tschopp JF, Emr SD, Field C, Schekman R.
J Bacteriol. 1986 Apr;166(1):313-8. doi: 10.1128/jb.166.1.313-318.1986. PMID: 3082856. 

39. Interorganelle transfer and glycosylation of yeast invertase in vitro.
Haselbeck A, Schekman R.
Proc Natl Acad Sci U S A. 1986 Apr;83(7):2017-21. doi: 10.1073/pnas.83.7.2017. PMID: 2421286. 

38. Morphological observations on the formation and stability of the crystalline arrays in the plasma membrane of Saccharomyces cerevisiae.
Sosinsky G, Schekman R, Glaeser RM.
J Ultrastruct Mol Struct Res. 1986 Jan;94(1):37-51. doi: 10.1016/0889-1605(86)90050-9. PMID: 3534113.

1985

37. Characterization of a gene product (Sec53p) required for protein assembly in the yeast endoplasmic reticulum.
Bernstein M, Hoffmann W, Ammerer G, Schekman R.
J Cell Biol. 1985 Dec;101(6):2374-82. doi: 10.1083/jcb.101.6.2374. PMID: 3905826. 

36. A test of clathrin function in protein secretion and cell growth.
Payne GS, Schekman R.
Science. 1985 Nov 29;230(4729):1009-14. doi: 10.1126/science.2865811. PMID: 2865811.

35. Invertase signal and mature sequence substitutions that delay intercompartmental transport of active enzyme.
Schauer I, Emr S, Gross C, Schekman R.
J Cell Biol. 1985 May;100(5):1664-75. doi: 10.1083/jcb.100.5.1664. PMID: 3886671. 

34. Protein localization and membrane traffic in yeast.
Schekman R.
Annu Rev Cell Biol. 1985;1:115-43. doi: 10.1146/annurev.cb.01.110185.000555. PMID: 3916315. 

1984

33. Defective plasma membrane assembly in yeast secretory mutants.
Tschopp J, Esmon PC, Schekman R.
J Bacteriol. 1984 Dec;160(3):966-70. doi: 10.1128/jb.160.3.966-970.1984. PMID: 6094514. 

32. Invertase beta-galactosidase hybrid proteins fail to be transported from the endoplasmic reticulum in Saccharomyces cerevisiae.
Emr SD, Schauer I, Hansen W, Esmon P, Schekman R.
Mol Cell Biol. 1984 Nov;4(11):2347-55. doi: 10.1128/mcb.4.11.2347-2355.1984. PMID: 6440005. 

31. Isolation of glucose-containing high-mannose glycoprotein core oligosaccharides.
Tsai PK, Ballou L, Esmon B, Schekman R, Ballou CE.
Proc Natl Acad Sci U S A. 1984 Oct;81(20):6340-3. doi: 10.1073/pnas.81.20.6340. PMID: 6387703. 

30. Early steps in processing of yeast glycoproteins.
Esmon B, Esmon PC, Schekman R.
J Biol Chem. 1984 Aug 25;259(16):10322-7. PMID: 6381483. 

29. Glycosylation and processing of prepro-alpha-factor through the yeast secretory pathway.
Julius D, Schekman R, Thorner J.
Cell. 1984 Feb;36(2):309-18. doi: 10.1016/0092-8674(84)90224-1. PMID: 6420074.

28. Genes required for completion of import of proteins into the endoplasmic reticulum in yeast.
Ferro-Novick S, Hansen W, Schauer I, Schekman R.
J Cell Biol. 1984 Jan;98(1):44-53. doi: 10.1083/jcb.98.1.44. PMID: 6368572. 

27. Yeast secretory mutants that block the formation of active cell surface enzymes.
Ferro-Novick S, Novick P, Field C, Schekman R.
J Cell Biol. 1984 Jan;98(1):35-43. doi: 10.1083/jcb.98.1.35. PMID: 6368571. 

1983

26. An MF alpha 1-SUC2 (alpha-factor-invertase) gene fusion for study of protein localization and gene expression in yeast.
Emr SD, Schekman R, Flessel MC, Thorner J.
Proc Natl Acad Sci U S A. 1983 Dec;80(23):7080-4. doi: 10.1073/pnas.80.23.7080. PMID: 6359161. 

25. Two distinct subfractions in isolated Saccharomyces cerevisiae plasma membranes.
Tschopp J, Schekman R.
J Bacteriol. 1983 Oct;156(1):222-9. doi: 10.1128/jb.156.1.222-229.1983. PMID: 6137475. 

24. Export of major cell surface proteins is blocked in yeast secretory mutants.
Novick P, Schekman R.
J Cell Biol. 1983 Feb;96(2):541-7. doi: 10.1083/jcb.96.2.541. PMID: 6339519. 

23. Yeast secretory mutants: isolation and characterization.
Schekman R, Esmon B, Ferro-Novick S, Field C, Novick P.
Methods Enzymol. 1983;96:802-15. doi: 10.1016/s0076-6879(83)96068-8. PMID: 6361466. 

1982

22. Calcium control of Saccharomyces cerevisiae actin assembly.
Greer C, Schekman R.
Mol Cell Biol. 1982 Oct;2(10):1279-86. doi: 10.1128/mcb.2.10.1279-1286.1982. PMID: 6757718. 

21. Actin from Saccharomyces cerevisiae.
Greer C, Schekman R.
Mol Cell Biol. 1982 Oct;2(10):1270-8. doi: 10.1128/mcb.2.10.1270-1278.1982. PMID: 6217414. 

20. Early stages in the yeast secretory pathway are required for transport of carboxypeptidase Y to the vacuole.
Stevens T, Esmon B, Schekman R.
Cell. 1982 Sep;30(2):439-48. doi: 10.1016/0092-8674(82)90241-0. PMID: 6754086.

1981

19. Order of events in the yeast secretory pathway.
Novick P, Ferro S, Schekman R.
Cell. 1981 Aug;25(2):461-9. doi: 10.1016/0092-8674(81)90064-7. PMID: 7026045. 

18. Compartmentalized assembly of oligosaccharides on exported glycoproteins in yeast.
Esmon B, Novick P, Schekman R.
Cell. 1981 Aug;25(2):451-60. doi: 10.1016/0092-8674(81)90063-5. PMID: 7026044.

1980

17. Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway.
Novick P, Field C, Schekman R.
Cell. 1980 Aug;21(1):205-15. doi: 10.1016/0092-8674(80)90128-2. PMID: 6996832.

16. Localized secretion of acid phosphatase reflects the pattern of cell surface growth in Saccharomyces cerevisiae.
Field C, Schekman R.
J Cell Biol. 1980 Jul;86(1):123-8. doi: 10.1083/jcb.86.1.123. PMID: 6998984. 

15. Lyticase: endoglucanase and protease activities that act together in yeast cell lysis.
Scott JH, Schekman R.
J Bacteriol. 1980 May;142(2):414-23. doi: 10.1128/jb.142.2.414-423.1980. PMID: 6991473. 

1979

14. Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae.
Novick P, Schekman R.
Proc Natl Acad Sci U S A. 1979 Apr;76(4):1858-62. doi: 10.1073/pnas.76.4.1858. PMID: 377286. 

13. Localized deposition of chitin on the yeast cell surface in response to mating pheromone.
Schekman R, Brawley V.
Proc Natl Acad Sci U S A. 1979 Feb;76(2):645-9. doi: 10.1073/pnas.76.2.645. PMID: 16592617. 

12. Domains of receptor mobility and endocytosis in the membranes of neonatal human erythrocytes and reticulocytes are deficient in spectrin.
Tokuyasu KT, Schekman R, Singer SJ.
J Cell Biol. 1979 Feb;80(2):481-6. doi: 10.1083/jcb.80.2.481. PMID: 457754. 

1976

11. Clustering and endocytosis of membrane receptors can be induced in mature erythrocytes of neonatal but not adult humans.
Schekman R, Singer SJ.
Proc Natl Acad Sci U S A. 1976 Nov;73(11):4075-9. doi: 10.1073/pnas.73.11.4075. PMID: 1069294. 

1975

10. Ten proteins required for conversion of phiX174 single-stranded DNA to duplex form in vitro. Resolution and reconstitution.
Schekman R, Weiner JH, Weiner A, Kornberg A.
J Biol Chem. 1975 Aug 10;250(15):5859-65. PMID: 1097445. 

1974

9. Multienzyme systems of DNA replication.
Schekman R, Weiner A, Kornberg A.
Science. 1974 Dec 13;186(4168):987-93. doi: 10.1126/science.186.4168.987. PMID: 4620044. 

1973

8. A new form of DNA polymerase 3 and a copolymerase replicate a long, single-stranded primer-template.
Wickner W, Schekman R, Geider K, Kornberg A.
Proc Natl Acad Sci U S A. 1973 Jun;70(6):1764-7. doi: 10.1073/pnas.70.6.1764. PMID: 4578443. 

1972

7. Initiation of DNA synthesis: synthesis of phiX174 replicative form requires RNA synthesis resistant to rifampicin.
Schekman R, Wickner W, Westergaard O, Brutlag D, Geider K, Bertsch LL, Kornberg A.
Proc Natl Acad Sci U S A. 1972 Sep;69(9):2691-5. doi: 10.1073/pnas.69.9.2691. PMID: 4560696. 

6. RNA synthesis initiates in vitro conversion of M13 DNA to its replicative form.
Wickner W, Brutlag D, Schekman R, Kornberg A.
Proc Natl Acad Sci U S A. 1972 Apr;69(4):965-9. doi: 10.1073/pnas.69.4.965. PMID: 4554537. 

1971

5. A possible role for RNA polymerase in the initiation of M13 DNA synthesis.
Brutlag D, Schekman R, Kornberg A.
Proc Natl Acad Sci U S A. 1971 Nov;68(11):2826-9. doi: 10.1073/pnas.68.11.2826. PMID: 4941987. 

4. Polynucleotide ligase and phiX174 single strand synthesis.
Schekman RW, Ray DS.
Nat New Biol. 1971 Jun 9;231(23):170-3. doi: 10.1038/newbio231170a0. PMID: 4931976. 

3. The mechanism of replication of phi X174 single-stranded DNA. III. An enzymic study of the structure of the replicative form II DNA.
Schekman RW, Iwaya M, Bromstrup K, Denhardt DT.
J Mol Biol. 1971 Apr 28;57(2):177-99. doi: 10.1016/0022-2836(71)90340-8. PMID: 4931510. 

1969

2. Replication of bacteriophage M13. III. Identification of the intracellular single-stranded DNA.
Ray DS, Schekman RW.
J Mol Biol. 1969 Aug 14;43(3):645-7. doi: 10.1016/0022-2836(69)90365-9. PMID: 5401239.  

1. Replication of bacteriophage M13. I. Sedimentation analysis of crude lysates of M13-infected bacteria.
Ray DS, Schekman RW.
Biochim Biophys Acta. 1969 Apr 22;179(2):398-407. PMID: 4890599.